Objective: To probe into the role of clinical pharmacists in the pharmaceutical care of children with nephrotic syndrome complicated with drug-induced liver injury. Methods: Abnormal liver function occurred in 1 child with nephrotic syndrome during treatment. The clinical pharmacists participated into analysis of the causes of liver function abnormalities

and considered drug-induced factors after excluding other potential causes. By referring to the American LiverTox database and Chinese Hepatox database

as well as relevant guidelines and literature

the clinical pharmacists recommended that clinicians to discontinue suspected drugs and provided alternative treatment options

performed adverse drug reactions monitoring and telephone follow-up. Results: Clinical pharmacists determined that captopril was likely to induce hepatic abnormalities in the child

and clinicians adopted the recommendation to discontinue captopril and used fosinopril as an alternative treatment. Furthermore

clinical pharmacists suggested clinicians adjusted prednisone to methylprednisolone for long-term administration and selected compound glycyrrhine for liver protection treatment

and the liver function of the child returned to normal state after adjustment of the above treatment regimen. Conclusion: Clinical pharmacists can assist clinicians in identifying drug-related factors contributing to liver injury in children

and provide strategies for treatment adjustments

thereby reducing the risk of severe liver injury in children.